Electrochemical synthesis of quinolines

This report outlines an intramolecular oxidative annulation process involving N-substituted o-amino phenylacetylene, performed under electrochemical conditions, which yields substituted quinoline in an undivided cell at room temperature. The reaction features mild condition, requiring neither external oxidants nor metals and achieves yields that range from good to excellent. Moreover, the synthetic potential of quinoline has been demonstrated resulting in synthesis of substituted polycyclic isoindolinone and (aza)isoindolinone compounds.