DOI: 10.1002/cjoc.202401029 ISSN: 1001-604X
Electrochemical N–H Methylsulfoxidation of Sulfoximines with DMSO
Qing‐Ru Zhu, Gen Liu, Yongxiang Wang, Zhubing Xiao, Hui Gao, Pei‐Long Wang Comprehensive Summary
The N–H methylsulfoxidation of sulfoximines using DMSO as a methylsulfinyl source, induced by electrochemistry, has been developed. This method is the first example of an electrochemical reaction in which DMSO serves as a methylsulfinyl source. Unlike previous electrochemical reactions involving DMSO as a substrate, which exclusively proceed via radical mechanisms, this reaction follows an S‐cation pathway. A wide range of N‐methylsulfinyl sulfoximines were successfully obtained.