DOI: 10.1039/d6sd00111d ISSN: 2635-0998
Electrochemical DNA hairpin sensors for differentiating small molecule intercalation from minor groove binding
Kiara Thompson, Kian Barnes, Saron Yoseph, Vincent Clark, J. D. Mahlum, Ananya Majumdar, Philip S. Lukeman, Netzahualcóyotl Arroyo-CurrásA rationally designed DNA hairpin sensor converts intercalator binding into an electrochemical signal through target-induced hairpin stabilization. The platform selectively identifies DNA intercalators over minor groove binders.