DOI: 10.3390/biom14010037 ISSN: 2218-273X
Efficient Stereo-Selective Fluorination on Vitamin D3 Side-Chain Using Electrophilic Fluorination
Fumihiro Kawagoe, Sayuri Mototani, Atsushi Kittaka- Molecular Biology
- Biochemistry
Our research regarding side-chain fluorinated vitamin D3 analogues has explored a series of efficient fluorination methods. In this study, a new electrophilic stereo-selective fluorination methodology at C24 and C22 positions of the vitamin D3 side-chain was developed using N-fluorobenzenesulfonimide (NFSI) and CD-ring imides with an Evans chiral auxiliary (26,27,30).