Efficacy of intraperitoneal bupivacaine alone or in combination with dexmedetomidine or magnesium sulfate for postoperative analgesia after laparoscopic cholecystectomy
Ahmed S.M. Sayed, Tawfeq M.N. El-Deen, Mahmoud A.A. El-Salam, Mohamed A. GadallahBackground and aim
Laparoscopic cholecystectomy (LC) is followed by significant pain. This study aimed to evaluate the safety and effectiveness of intraperitoneal (IP) bupivacaine alone, IP bupivacaine with dexmedetomidine, and IP bupivacaine with magnesium sulfate for post-LC analgesia.
Patients and methods
A randomized double-blinded controlled trial was conducted on 60 patients (ASA class I–II) who underwent LC. All patients were assigned randomly into three groups: group B received IP bupivacaine 0.5% (25 ml+25 ml saline; group BD received IP bupivacaine 0.5% (25 ml)+dexmedetomidine 1 μg/kg; group BM received IP bupivacaine 0.5% (25 ml)+magnesium sulfate 15 mg/kg (diluted to 25 ml).
Results
Time to the first analgesic demand was delayed in group BD (134.81±19.23 min) compared with group BM (112.62±33.37 min) and group B (59.11±22.70 min) (
Conclusion
IP bupivacaine with dexmedetomidine provides superior postoperative analgesia, prolonged pain relief, reduced opioid consumption, and higher patient satisfaction compared with bupivacaine alone or with magnesium sulfate in LC.