DOI: 10.4103/tdj.tdj_253_25 ISSN: 1687-8574

Efficacy of combined scaffolds and sodium hypochlorite in regenerative endodontics of immature teeth (in-vivo study)

Hanan Arb, Abeer Darrag, Neveen Shaheen, Dina Attia
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Purpose

To evaluate revascularization of nonvital immature permanent teeth using blood clot (BC), platelet-rich fibrin (PRF), and collagen scaffolds combined with different sodium hypochlorite (NaOCl) concentrations (0.5–2.5%) clinically and radiographically using cone-beam computed tomography.

Patients and methods

Forty-eight patients aged between 9 and 25 years requiring endodontic therapy of nonvital immature permanent anterior teeth were selected for this study. Patients were randomly divided into six equal groups ( n = 8) according to the type of scaffold and NaOCl concentrations used; group I: BC/0.5% NaOCl, group II: BC/2.5% NaOCl, group III: PRF/0.5% NaOCl, group IV: PRF/2.5% NaOCl, group V: collagen/0.5% NaOCl, and group VI: collagen/2.5% NaOCl. Patients were evaluated after 6 and 12 months clinically for presence or absence of pain, swelling, sinus tract, mobility or discoloration and radiographically using cone-beam computed tomography for any changes in root length, apical foramen diameter, root canal width, and periapical lesion size.

Results

Clinical and radiographic evaluations showed great improvements for all cases when compared to the baseline. PRF showed better results compared to collagen and BC with no statistically significant difference. Furthermore, there is no statistically significant difference between 0.5% and 2.5% NaOCl concentrations.

Conclusions

PRF scaffold is more effective in regenerative endodontic treatments (RETs) compared to BC and collagen scaffolds. Natural scaffolds provide a reliable outcome in RETs. Lower concentrations of NaOCl irrigation provide a satisfactory result during RETs. RETs are considered as a valuable choice for treating nonvital immature permanent teeth.

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