Effects of Liraglutide on Energy Intake in Adolescents With Persistent Obesity After Vertical Sleeve Gastrectomy
Bao‐Vi C. Tran, Anna Zenno, Nazrat M. Mirza, Evan Nadler, Sheila M. Brady, Otiti A. Mayo, Alexa P. Lyman, Stephanie T. Chung, Kong Y. Chen, Peter Walter, Hongyi Cai, Shanna B. Yang, Sara A. Turner, Jack A. Yanovski, Bobby K. CheonABSTRACT
Background
In adolescents with obesity ≥ 1‐year post‐vertical sleeve gastrectomy (VSG), a pilot trial of liraglutide demonstrated a 4.3% BMI reduction. This secondary analysis evaluated energy intake changes (∆EI) and associations of ∆EI with oral glucose tolerance test (OGTT) outcomes and end‐of‐trial liraglutide plasma concentrations.
Methods
At baseline and after 4 months of liraglutide, participants completed a standardised buffet meal following a 2‐h OGTT. Liraglutide plasma area under the curves (AUCs) were quantified using LC–MS/MS.
Results
Twenty‐seven participants (18.1 ± 2.0 years; BMI: 40.4 ± 7.3 kg/m 2 ) completed buffet meals at both visits. Mean energy intake decreased by 161.7 ± 264.3 kcal ( p = 0.04) and food mass by 72.5 ± 123.4 g ( p = 0.02), with proportional reductions in absolute macronutrient intake but no change in macronutrient distribution. Neither Liraglutide AUC ( n = 17) nor OGTT outcomes were significantly associated with ∆EI or changes in body weight.
Conclusions
In adolescents post‐VSG treated with liraglutide, overall food intake decreased without significant changes in macronutrient composition.