DOI: 10.1097/rd9.0000000000000173 ISSN: 2096-2924

Effects of Clostridium butyricum and Bacillus coagulans on Physical Health Parameters in Older Men

Jun Wu, Hua-Jun Zheng, Peng-Hui Cheng, Qun Kuang, Mei Sun, Jian-Hui Li, Xiao-Hua Yu, Jun-Biao Zheng, Jun Wang, Liang Chen, Jun Qian, Fang Xu, Hui-Juan Shi
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Objective:

Aging is commonly associated with a decline in immune function, hormonal imbalances, insomnia, constipation, erectile dysfunction, and general muscle weakness. To address these complex conditions, our study used probiotic therapy.

Methods:

We investigated the effects of two spore-forming probiotics, Clostridium butyricum and Bacillus coagulans , on health parameters in 126 men aged 48–64 years through a population-based intervention.

Results:

This intervention notably improved age-related conditions, particularly erectile function (measured by the Erectile Function Scale Index [EFSI]), bowel movement regularity, and sleep quality. Among 35 blood biochemical parameters, 19 showed significant changes post-treatment, including those related to immune response, hormone levels, inflammation, and lipid metabolism. Some blood parameters associated with probiotic treatment were identified using exploratory machine learning analysis.

Conclusions:

The results suggest that supplementation with Clostridium butyricum and Bacillus coagulans may be associated with improvements in certain age-related health parameters in older men.

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