Effects of a 6-Month Intervention on Body Weight and Cardiometabolic Parameters Based on the Korean Diabetes Prevention Study
Suk Chon, Soo Jin Yun, Hyunji Sang, Sang Youl Rhee, Su Jin Jeong, In Joo Kim, Moon-Kyu Lee, Kyong Soo Park, Kwan-Woo Lee, Bong-Soo Cha, Choon Hee Chung, Tae Sun Park, In-Kyung Jeong, Won-Young Lee, In-Kyu Lee, Sei Hyun Baik, Joong-Yeol Park, Tae Keun Oh, Hyuk-Sang Kwon, Jeong-Taek Woo,Background: This study evaluated the 6-month effects of the Korean Diabetes Prevention Study (KDPS) interventions on body weight and cardiometabolic parameters in adults with prediabetes.Methods: Adults aged 30–70 years with body mass index ≥23 kg/m² were randomized to lifestyle modification (LSM), metformin (MET), or standard management (STM). The KDPS-LSM program combined intensive nutrition education and LSM including 10 key healthy habits with personalized counseling, targeting ≥5% weight loss in 6 months followed by long-term maintenance. Cardiometabolic parameters were assessed before and after the intervention (Trial registration: CRIS KCT0002260, NCT02981121).Results: Of 701 completers (262 STM, 222 LSM, 217 MET), all groups showed significant weight reduction (−0.7 kg STM, −2.3 kg LSM, −2.0 kg MET; P<0.001). The LSM group achieved the largest weight reduction and the highest ≥5% weight-loss rate. Glycemic indices remained largely stable in the LSM and MET groups, whereas FPG increased significantly in the STM group; a significant reduction in HbA1c was observed only in the MET group. Even modest (<5%) weight loss conferred cardiometabolic benefits, and greater loss correlated with higher adherence to LSM or higher MET exposure.Conclusion: All KDPS interventions reduced body weight after 6 months, with LSM providing the best weight outcomes and MET showing the most favorable glycemic effects.