Effectiveness of Treatment Modalities for Dentin Hypersensitivity in Children with Molar-Incisor Hypomineralization: A Systematic Review and Meta-Analysis
T Ünal, FN Kızılay, SE ÜnalIntroduction:
Dentin hypersensitivity associated with molar-incisor hypomineralization (MIH) is a significant clinical challenge that can adversely affect children’s quality of life.
Aim:
This systematic review and meta-analysis evaluated the effectiveness of treatment modalities for reducing hypersensitivity in children with MIH.
Methods:
A systematic search of PubMed, Scopus, Web of Science, CENTRAL, and EMBASE was conducted between May 5 and 15, 2025, in accordance with PRISMA 2020. After duplicate removal, 179 records were screened. Twenty-one full-text reports were sought, 11 were assessed for eligibility, and 3 were excluded, including 1 study lacking an eligible comparator/control group for inclusion in the review. Eight randomized controlled trials were included in the qualitative synthesis, of which five randomized controlled trials (
Results:
The pooled estimate demonstrated a statistically significant reduction in hypersensitivity in favor of intervention groups (SMD = −0.39; 95% confidence interval − 0.71 to − 0.06;
Conclusion:
Available treatments may reduce MIH-related hypersensitivity; however, no modality demonstrated clear superiority. Further randomized trials with standardized outcomes and longer follow-up are needed.