Effect of preoperative midazolam anxiolysis on anesthetic gas consumption: A randomized controlled trial
Ersel Gulec, Mediha Turktan, Zehra Hatipoglu, Neslihan Eraslan, Dilek OzcengizBackground:
Adult patients often experience preoperative anxiety that can influence their anesthetic requirements. We investigated the effect of a preoperative midazolam anxiolytic dose on intraoperative sevoflurane consumption.
Methods:
This prospective, randomized, double-blind, placebo-controlled study involved 80 patients undergoing elective surgery. Participants were randomized to receive either intravenous midazolam (0.04 mg/kg) or saline preoperatively. Preoperative anxiety assessment was conducted using the short version of the State-Trait Anxiety Inventory. The primary outcome was cumulative sevoflurane consumption within the first hour of surgery. Secondary outcomes included minimum alveolar concentration (MAC), MAC-hour, inspiratory and end-tidal sevoflurane concentrations, and hemodynamic variables.
Results:
Sevoflurane consumption in 60 minutes was comparable between the midazolam (mean ± standard deviation: 24.2 ± 3.9 mL) and control (25.2 ± 4.1 mL) groups (
Conclusion:
Preoperative anxiolytic dose of midazolam administration did not significantly reduce intraoperative sevoflurane consumption, and preoperative anxiety levels were not associated with sevoflurane requirements.