Effect of Plant Secondary Metabolites against Lung Cancer: A Comprehensive Review on Apoptosis Induction and Synergistic Potential

Abstract:

Lung carcinoma is the most ubiquitous and fundamental cause of cancer-related mortality globally. The conventional therapeutic approaches for lung cancer have consistently encountered several challenges and complexities, prompting the exploration of novel tactics for the detection and management of cancer. Lung cancer is a highly preventable disease, and early-stage detection significantly improves patient’s survival rates. Several distinct medicinal substances from plants aid in treating human illnesses and promoting good health. Plants, including Astragalus propinquus, Curcuma longa, Anethum graveolens, Allium cepa, etc., are utilized as medicines to treat lung cancer. It can be effectively treated using plant secondary metabolites like flavonoids, phenolics, terpenoids, steroids, alkaloids, and polyphenols. This review describes the structures of plant metabolites and the process by which they induce apoptosis against lung cancer. This data will assist in the comprehensive awareness and understanding of the factors that combat phytochemicals against lung cancers and the production of new anti-cancer medications.