Effect of Friend Virus on Serum Albumin Synthesis in Mouse Liver

Summary

The rate of serum albumin synthesis in liver and its level in blood plasma were determined in Swiss mice in advanced stages of the neoplastic syndrome produced by the anemia-inducing strain of Friend virus (FVA). The animals with splenomegaly and progressive invasion of the liver by pathologic erythroblasts developed a high hypervolemia. A slight decrease in the plasma albumin level was noted at the beginning of liver invasion; in more advanced disease stages, normal values returned. Throughout the syndrome, the rate of albumin synthesis in the liver did not change. The dilution anemia, due primarily to hypervolemia in hepatosplenomegalic animals, was not accompanied by dilution of the plasma proteins.