Effect of Dry Eye and Ocular Surface Treatment on Agreement and Repeatability of Corneal Astigmatism Measurements Among Three Devices
Songlian Wang, Xuanqiao Lin, Runhan Shi, Lifang Bai, Dongjin Qian, Jin YangPurpose:
To evaluate the effect of dry eye disease (DED) and ocular surface treatment on the agreement and repeatability of corneal astigmatism measurements obtained using IOLMaster 700, Pentacam, and iTrace in patients with age-related cataract.
Setting:
Eye, Ear, Nose, and Throat Hospital of Fudan University, Shanghai, China.
Design:
Prospective, single-center study.
Methods:
A total of 313 eyes of patients with age-related cataract were included. Eyes with DED received 0.3% sodium hyaluronate eye drops for 2 weeks and were re-examined after treatment. Corneal astigmatism measurements were obtained using IOLMaster 700, Pentacam, and iTrace before pupil dilation. The main parameters included keratometric corneal astigmatism, total corneal astigmatism, and their vector components. Interdevice agreement was assessed using Bland-Altman analysis, and test-retest repeatability was evaluated using within-subject standard deviation, test-retest repeatability, and intraclass correlation coefficients.
Results:
Compared with the control group, eyes at DED baseline showed wider limits of agreement and poorer TRT for both scalar astigmatism parameters and vector components. After ocular surface treatment, LoA width decreased by 50.5%–62.5% for KCA and 19.9%–29.0% for TCA across the three device comparisons. KCA repeatability improved significantly after treatment for IOLMaster 700 and iTrace, whereas significant improvement in TCA repeatability was observed only for IOLMaster 700. Device- and parameter-specific differences persisted after treatment.
Conclusions:
DED was associated with reduced agreement and repeatability of corneal astigmatism measurements obtained using IOLMaster 700, Pentacam, and iTrace. Short-term ocular surface treatment was associated with improved measurement stability.