DOI: 10.1093/cid/ciad517 ISSN:
ECMO-Dependent Fulminant Melioidosis from Caspase 4 Mutation Reversed by Interferon Gamma Therapy
Aseervatham Anusha Amali, Sharada Ravikumar, Wei Leong Chew, Zhaohong Tan, Qi Hui Sam, Kaiwen W Chen, Dave Boucher, Graeme Maclaren, Louis Yi Ann Chai- Infectious Diseases
- Microbiology (medical)
Abstract
We describe bedside-to-bench immunological and genetic elucidation of defective pyroptosis attributable to novel Caspase 4 defect mediating pathogen-triggered inflammatory programmed cell death, in setting of severe pneumonia and abscess-forming melioidosis in an overtly healthy host failing to clear Burkholderia pseudomallei, and how targeted adjunctive biological therapy led to successful outcome.