Dynamics of changes in markers of non-specific inflammation in coronary heart disease

Objective: To analyze the dynamics of changes in the level of high-sensitivity C-reactive protein (hs-CRP) and interleukin-6 in patients with various clinical manifestations of coronary heart disease. Materials and Methods: The study involved examining 30 patients with various stages of coronary artery disease (CAD). The average age of the participants was 63.4±1.5 years, and all had documented CAD. Patients were selected from each clinical form of the disease: 10 people with CAD angina pectoris functional class II, 10 people with small-focal myocardial infarction in the acute period, and 10 people with large-focal myocardial infarction, complicated. The study included 12 women (40.0%) and 18 men (60.0%). Results: Studies show that as coronary artery disease progresses, from initial ischemic processes to the development of myocardial necrosis, an increase in the concentration of non-specific inflammatory markers is observed. The highest levels of C-reactive protein are observed in patients with complicated forms of myocardial infarction, reaching 8.2±0.25 mg/L and exceeding control values by 3.3 times. Interleukin-6 concentrations also increase significantly, reaching a maximum in the group of patients with complicated myocardial infarction, averaging 24.2±0.34 pg/ml, which is 3.1 times higher than control values. Conclusion: The cytokine interleukin-6, in combination with high-sensitivity C-reactive protein, are the most reactive markers, allowing them to be used as important factors in the development and progression of coronary artery disease. Determining CRP and IL-6 levels is essential for predicting the risk of vascular complications.