DOI: 10.1039/d6tb01620k ISSN: 2050-750X

Dynamic supramolecular assembly and pH-responsive doxorubicin release in zwitterionic hyaluronate–quercetin nanoparticles

Ifra Aslam, Sunisa Thongsom, Chamaiporn Supachettapun, Titilope John Jayeoye, Lucrezia Desiderio, Ahmed Subrati, Paolo Di Gianvincenzo, Eduart Gutiérrez-Pineda, Kanokwan Sansanaphongpricha, Nattida Chotechuang, Mauro Giustini, Chanchai Boonla, Sergio Enrique Moya, Nongnuj Muangsin

A pH-responsive, supramolecular zwitterionic nanocarrier based on the self assembly of quaternized hyaluronate conjugated with quercetin (QHQ) is presented for the enhanced intracellular delivery of the anticancer drug doxorubicin (Dx).

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