Durability of Ultra‐Low Temperature Cryoablation Lesions in Atrial Fibrillation: Insights From Repeat Ablation Procedures
Bob G. S. Abeln, Lucio Addeo, Tom De Potter, Lucas V. A. BoersmaABSTRACT
Background
Ultra‐low temperature cryoablation (ULTC) is a technique designed to rapidly cool cardiac tissue to extremely low temperatures, enabling the creation of ablation lesions for the treatment of atrial fibrillation (AF). Prior studies have demonstrated low rates of arrhythmia recurrence, but little is known about ablation lesion durability.
Methods
Patients undergoing repeat ablation were selected from the CryoCure2 (NCT02839304) and iCLAS PMCF(NCT05416086) studies. Baseline patient and ULTC procedure characteristics were evaluated. During repeat ablation, ULTC ablation lesions were assessed for electrical block, including segment‐based assessment of pulmonary vein (PV) ablation lesions. Arrhythmia outcomes after repeat ablation were evaluated.
Results
Twenty‐five patients were included in the cohort: Age 68 ± 7 years, male 68%, persistent AF 68%, LAVI 42 ± 24 mL/m2. During index procedure, ULTC was used to target the PVs in all patients, the left atrium posterior wall (LAPW) in 15 patients, the lateral mitral isthmus (LMI) in five patients and the cavotricuspid isthmus (CTI) in two patients. At repeat ablation, PV reconnection was observed in 21/25 patients (55/100 PVs reconnected), and reconnection occurred most often in the anterior segments of the left PVs. The LAPW lesion was incomplete in 4/15 patients, the LMI in 3/5 and the CTI in 1/2. After repeat ablation, 10/25 patients had arrhythmia recurrence.
Conclusion
Reconnection of ablation targets during repeat ablation for arrhythmia recurrence following ULTC occurred at rates comparable to those observed with conventional thermal ablation modalities. The anterior side of the left PVs appears to be reconnected most often.