DOI: 10.17567/currresdentsci.1520408 ISSN: 2822-2555

Drug Delivery System for Bone Regeneration Treatment: A Scoping Review

Yunia Rakhmatia, Firman Andika, Setyawan Bonifacius, Rasmi Rikmasari, Sri Tjahajawati, Eriska Riyanti
Show PDF Cite
Objective: The aim of this study is to examine the potential of drug delivery systems (DDS) in advancing bone regeneration therapies by evaluating their efficacy, materials, and therapeutic agents, with the goal of guiding future clinical applications and improving treatment outcomes.Methods: A scoping review was conducted using PRISMA-ScR guidelines, covering studies published between 2014 and 2025 across databases including PubMed, Cochrane, Scopus, Science Direct, Springer, and DOAJ.Results: Forty-five eligible studies were identified, comprising in vitro, in vivo, and clinical investigations. Therapeutic agents evaluated included bone morphogenetic proteins (BMPs), natural compounds, and antibiotics, delivered through carriers such as hydrogels, collagen composites, calcium phosphates, nanomaterials, and 3D-printed scaffolds. Multifunctional DDS showed promising outcomes, with combinations like BMP-2 and vascular endothelial growth factor (VEGF) or statins and platelet-rich fibrin demonstrating enhanced regenerative capacity. DDS integrating infection control with bone healing further underscored their clinical potential. Overall, DDS represent an innovative approach to bone repair, though wider clinical adoption requires resolving safety, methodological, and scalability challenges to optimize patient-centered applications.Keywords: Drug delivery system, bone regeneration, scaffold, drug clinical, nanoparticle

More from our Archive