DOI: 10.1039/d6md00729e ISSN: 2632-8682
DprE1 inhibitors in tuberculosis: integrating structural binding determinants, IC 50 –MIC translation, and physicochemical constraints for rational drug design
Fady H. Fayek, Mai H. A. Mousa, Mona F. Said, Hanan H. Georgey, Nagwa M. Abdel GawadDecaprenylphosphoryl-β-
d
-ribose 2′-epimerase (DprE1) has emerged as one of the most validated and clinically relevant targets for antitubercular drug discovery.