DOI: 10.1039/d4pm00053f ISSN: 2976-8713

Doxorubicin-Polysorbate 80 conjugates: targeting effective and sustained delivery to the brain

S. Ram Prasad, Sruthi Sudheendran Leena, Ani Deepthi, A. N. Resmi, Ramapurath S. Jayasree, K. S. Sandhya, A. Jayakrishnan
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Herein, doxorubicin (DOX) was conjugated to polysorbate 80 (PS 80). The DOX-PS 80 conjugate exhibited 3-fold higher blood brain barrier permeability than free DOX and released the DOX in a more sustained manner, highlighting the significance of polysorbate conjugates in addressing brain disorders.

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