Dose–Response Relationship Between Triglyceride Glucose‐Waist Height Ratio Index and Cardiometabolic Multimorbidity Among Chinese Middle‐Aged and Older People
Lingling Li, Zongliang Yu, Yixuan Feng, Changxin Sun, Lanqing Hu, Xinyi Liu, Liang Li, Min Wu, Longtao LiuABSTRACT
Background
Cardiometabolic multimorbidity (CMM) is a growing public health challenge. The triglyceride glucose‐waist height ratio (TyG‐WHtR) is a novel index linked to metabolic disorders. This study explores the dose–response relationship between TyG‐WHtR and CMM.
Methods
Data from the China Health and Retirement Longitudinal Study (CHARLS), including the 2011 baseline survey and the 2018 follow‐up survey with an average follow‐up duration of 7.0 years, were analyzed. Multivariate logistic regression and restricted cubic spline models assessed the TyG‐WHtR–CMM relationship, adjusting for covariates.
Results
The study enrolled 6674 individuals, and 1140 patients with cardiometabolic multimorbidity and 5534 patients with non‐cardiometabolic multimorbidity were documented over an average follow‐up duration of 7.0 years. The fourth TyG‐WHtR quartile group (Q4) had the highest CMM risk, with an odds ratio of 1.23 and a 95% confidence interval of 1.20–1.26. The restricted cubic spline regression model showed a nonlinear ( p < 0.001) association between TyG‐WHtR and CMM. Subgroup analyses showed that the positive association between TyG‐WHtR and CMM was evident among females and ex‐smokers. A notable interaction was observed between TyG‐WHtR and variables like age and marital status.
Conclusion
TyG‐WHtR is a potential CMM predictor, and maintaining it within a moderate range may help prevent CMM.