Disease-associated respiratory microbiota and metabolome changes in children with mycoplasma pneumoniae pneumonia
Taiyu Song, Shuo Zhang, Shuting Yu, Rui Li, Jun Shen, Guangling Liu, Jinya WangBackground
Mycoplasma pneumoniae pneumonia (MPP) is the most common community-acquired pneumonia in children. It is clinically characterized by insidious symptoms and common extrapulmonary complications. Severe patients are susceptible to pulmonary necrosis, pulmonary embolism, and bronchiolitis obliterans leading to permanent lung impairment.
Objectives
Exploring changes in the airway microenvironment of children with MPP.
Design
A prospective observational study was conducted to explore changes in the airway microenvironment of children with MPP.
Methods
In this study, 16S ribosomal RNA (rRNA) analysis and Metabolomics were used to analyze patient-derived bronchoalveolar lavage fluid to investigate changes in the airway microenvironment of patients with MPP.
Results
Microbiomics indicates characteristics such as reduced microbial diversity and altered abundance of specific genera against the background of Mycoplasma pneumoniae infection. The metabolomics analysis can identify changes in the host metabolite profile, including abnormal levels of glycerophospholipids and sphingolipids.
Conclusion
Integrating multi-omics data to elucidate the microbiota-metabolite-host interaction network may provide new strategies for precise classification, severe warning, and targeted therapy for MPP.