Discovery of tricyclic benzo[4,5]imidazo[2,1-
                    <i>b</i>
                    ]thiazole-3-hydroxyindolin-2-one hybrids as selective MAO-B and cholinesterase inhibitors

doi:10.1039/d6ra05787j

DOI: 10.1039/d6ra05787j ISSN: 2046-2069

Discovery of tricyclic benzo[4,5]imidazo[2,1- b ]thiazole-3-hydroxyindolin-2-one hybrids as selective MAO-B and cholinesterase inhibitors

Wagdy M. Eldehna, Ashraf K. El-Damasy, Jaeyeop Lim, Mariam M. Hewala, Zainab M. Elsayed, Tarfah Al-Warhi, Anwar A. El-Hamaky, Man-Jeong Paik, Gyochang Keum, Mohamed R. Elnagar, Hoon Kim, Haytham O. Tawfik

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A series of 13 novel 3-hydroxyindolin-2-one-benzo[4,5]imidazo[2,1- b ]thiazole hybrids was designed, synthesized, and evaluated as potential anti-Alzheimer agents targeting monoamine oxidase B (MAO-B) and cholinesterases.

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Discovery of tricyclic benzo[4,5]imidazo[2,1- b ]thiazole-3-hydroxyindolin-2-one hybrids as selective MAO-B and cholinesterase inhibitors

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