DOI: 10.1039/d6cb00124f ISSN: 2633-0679
Discovery of PROTACs recruiting the E3 ligase CHIP
Tokiha Masuda-Ozawa, Shusuke Tomoshige, Eisuke Hayakawa, Shinichi Sato, Kenji Ohgane, Fumiaki Ohtake, Minoru IshikawaTo expand the range of available E3 ligase resources, we developed novel proteolysis targeting chimeras (PROTACs) utilizing the carboxyl terminus of the Hsc70-interacting protein (CHIP) E3 ligase, which was previously unutilized.