DOI: 10.1039/d6ob01168c ISSN: 1477-0520
Discovery of novel cinnamamide derivatives as potent antifungal agents: design, synthesis, and biological evaluation
Yukang Liu, Xinyi Lu, Zhengyu Liu, Xiuyun Sheng, Jinkui Jia, Ting Zhao, Min Zhang, Liuqing Yang, Changsheng YaoTwo series of 25 new cinnamamides were synthesized. 8a showed broad-spectrum antifungal activity, with an EC 50 of 11.50 mg L −1 against S. sclerotiorum . Molecular docking suggested that 8a binds to SDH via hydrogen bonds and hydrophobic interactions.