DOI: 10.1039/d6md00412a ISSN: 2632-8682

Discovery of Aurora A/HDAC dual-target inhibitors: broad-spectrum in vitro antitumor activity and in vivo pharmacokinetic limitations

Lirong Zhang, Xuewen Zhang, Jie Zhong, Shiying Zhu, Jiamin Tan, Jianjun Chen, Mingzhu Zhao, Jian Zhang

This study aimed to develop dual-target inhibitors against Aurora A and HDACs, and identified Z20 as the optimal candidate via in vitro screening.

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