DOI: 10.1002/mrc.70150 ISSN: 0749-1581
Discovery and Structure Elucidation of a New Polyketide‐Derived Tetrahydropyran‐Containing Conjugated Fatty Acid Derivative Isolated From
Typhonium blumei
Bowen Zhang, Weijia Hu, Lu Dai, Qi Zhang, Yaling Deng, Tao Wang, Xiaomei Yu, Yu Hu, Kaifeng Hu ABSTRACT
A chemical investigation of the 95% EtOH extract of
Typhonium blumei
led to the isolation of a new polyketide‐derived tetrahydropyran‐containing conjugated fatty acid derivative (
1
), together with four known compounds (
2
–
5
). The structure of compound
1
was elucidated through comprehensive spectroscopic analyses, including 1D and 2D NMR spectra (
1
H NMR,
13
C NMR, DEPT, HSQC, HMBC, COSY, and NOESY), as well as HR‐ESI‐MS data. Its absolute configuration was further established by ECD calculation. The biosynthetic pathway for compound
1
was postulated. In addition, all the isolated compounds (
1
–
5
) were tested for their cytotoxic activities.