Outline
DOI: 10.1084/jem.20261476 ISSN: 0022-1007
Disarming FcR-dependent neutrophil activation in MPO-ANCA glomerulonephritis
Anne DavidsonUsing spatial profiling, Nishide et al. (https://doi.org/10.1084/jem.20260506) identified activated neutrophils in kidneys in anti-myeloperoxidase (MPO)–associated vasculitis. They developed one-armed antibodies that block pathogenic anti-MPO autoantibodies and prevent Fc receptor–mediated neutrophil activation, thereby attenuating renal injury in a passive transfer model. This nontoxic precision approach for disease treatment and flare prevention addresses a critical unmet need.
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