Diminishing Loss Sensitivity during Risky Decision-Making among Individuals with Gambling Disorder
H. Wei, G. Zhong, J. Liu, Y. Wei, X. Zhang, P. Yang, M. Zhao, J. DuIntroduction
Gambling disorder (GD) poses severe impacts on both individuals and society. Impairment in risky decision-making is a key behavioral characteristic of GD, but the underlying cognitive processes of these deficits remain unclear.
Objectives
This study decomposed the risky decision-making processes of GD with cognitive computational modeling.
Methods
A total of 100 participants with GD and 59 healthy controls (HCs) were recruited to complete psychometric assessments and the Balloon Analog Risk Task. Since GD involved abnormal loss evaluation in decision-making, we developed a novel cognitive model incorporating diminishing loss sensitivity and revealed the processes underlying the risk-taking behaviors with hierarchical Bayesian analysis.
Results
GD participants exhibited stronger loss aversion (
p
< 0.001) but faster-diminishing loss sensitivity (
p
< 0.001), regardless of severity, which drove the deficits in the overall performance of risky decision-making (
p
< 0.001) (Fig1). Overconfident prior belief (
p
= 0.002) and higher updating rate (
p
< 0.001) were observed among participants with GD (Fig3). Diminishing loss sensitivity was negatively correlated with impulsivity (
p
= 0.021), and loss aversion was negatively related to craving for gambling (
p
= 0.027) (Fig4).
Demographic and clinical characteristics of participants Table 1. Long description.