DOI: 10.1039/d6qo00639f ISSN: 2052-4129
Difluorocarbene-enabled N -deuteroformylation of amines and sulfonamides: access to formamide-1-d and N -CH 2
Sandeep Kumawat, Kallakuri Leela Manikya Naga Siva Jyothi, Venkata Narayana Kalevaru, Kotha Middela Rahul Reddy, Thota Munikrishna Teja, V. Pratap Reddy Gajulapalli, Sebastian Wohlrab, Kishore NatteA straightforward protocol for the deuteroformylation of complex amines and sulfonamides using BrCF 2 CO 2 K and D 2 O is described, providing versatile N -C(=O)D intermediates for the synthesis of N -CH 2 D compounds.