DOI: 10.1152/ajpheart.90012.2026 ISSN: 0363-6135
Differential contributions of CO 2 and blood pressure to cerebral macro- and microvascular reactivity in healthy adults
Takuya Kurazumi, Kartavya Sharma, Tsubasa Tomoto, Danilo Cardim, Junyeon Won, Rong ZhangThis study indicates that cerebrovascular reactivity to CO 2 (CVR-CO 2 ) differs between the macro- and microcirculation during both hypocapnia and hypercapnia and that relative contributions of CO 2 and blood pressure to these responses differ between vascular compartments during hypercapnia. These findings highlight the importance of considering compartment-specific regulatory mechanisms when interpreting CVR-CO 2 .