DOI: 10.1111/bph.70673 ISSN: 0007-1188

Dietary melatonin and its benefits on cardiovascular disease

Karabo Tisane, Carmelita Abrahams, Sandrine Lecour

Cardiovascular disease remains the leading cause of mortality globally, with a disproportionate burden in low‐ and middle‐income countries. Melatonin, a hormone primarily produced by the pineal gland, exhibits notable antioxidant, anti‐inflammatory and immunomodulatory properties that may confer cardiovascular benefits. Importantly, melatonin is also found in a wide range of dietary sources, raising the possibility that regular consumption of melatonin‐rich foods could offer a low‐cost, accessible strategy to support cardiovascular health. This review summarises knowledge on dietary melatonin and evaluates its potential to provide cardiovascular benefits.