DOI: 10.1039/d6ra06856a ISSN: 2046-2069
Diastereoselective synthesis of tetrahydroisoquinolines through the Pd-catalyzed post-Ugi transformations
Manzoor Zaman, Ainara Bekbolatova, Sofia D. Martynova, Azamat Begenov, Niyaz Amire, Muhammad Hasan, Azat M. Makhmet, Rakhmetulla Yerkassov, Andrey Belyaev, Adilet Bekmagambetov, Davit Hayrapetyan, Olga P. Pereshivko, Vsevolod A. Peshkov, Anatoly A. PeshkovA diastereoselective approach to sp 3 -enriched tetrahydroisoquinolines from Ugi-derived propargylamides via a sequence of Pd-catalyzed reductive Heck cyclization and heterogeneous double-bond hydrogenation is reported.