Outline
DOI: 10.1021/acs.joc.6c02145 ISSN: 0022-3263
Development of Reductive C-S Coupling for Preparing S -Aryl/alkyl Containing Peptides
Junhong Wang, Qiujin Fan, Chao Wang, Ying Bai, Xinxin ShaoAbstract
Herein, we report a robust reductive coupling of cysteine thiosulfonate derivatives with aryl/alkyl halides, enabling chemoselective modification of peptides. Using zinc as the reducing agent, it provides a divergent platform for construction of Csp3/Csp2─S bonds, featuring base-free reaction conditions, operational simplicity, and broad substrate compatibility.
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