Outline
DOI: 10.1039/d6ay01786j ISSN: 1759-9660
Development of a validated ultra-fast UPLC–MS/MS method for famciclovir quantification in human liver microsomes: NADPH-independent metabolic stability
Mohamed W. Attwa, Haitham AlRabiah, Adnan A. KadiThe UPLC–MS/MS method estimated FMV in HLM and showed that FMV depletion proceeded at a comparable rate with and without NADPH. So, FMV depletion in HLM is esterase-driven and NADPH-independent, consistent with its known bioactivation route.
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