Outline
DOI: 10.1039/d6ra06101j ISSN: 2046-2069
Development of 7-hydroxy-4-methylcoumarin–cyanoacrylate hybrids with antiproliferative activity against breast cancer cells: from molecular design to in vivo validation
Manar A. El-Zend, Ibrahim M. El-Deen, Zeinab Abdelkarim, Ibrahim M. Alanazi, Samar Zuhair Alshawwa, Essa M. SaiedIn the present study, a series of novel 6,8-dibromo-7-hydroxy-4-methylcoumarin–cyanoacrylate hybrids and their corresponding pyrazole derivatives were designed, synthesized, and evaluated for antiproliferative activity against breast cancer cells. Image created with the assistance of FigureLabs.
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