Development and Validation of an Interpretable Machine Learning Model for Inpatient Fall Risk Using Electronic Health Record Data

Background: Falls are the most common hospital-acquired adverse event, leading to extended hospitalization, loss of independence, disability, and premature death. Routine fall risk assessments are time-consuming, even with limited factors. An AI-derived fall prediction model can provide more comprehensive and comparably accurate risk predictions quickly and as often as needed. Objective: To develop and validate a fall prediction model for fall risk in adult inpatients. Methods: Patient records from 2016 were extracted from the adult inpatient database, including information from the Electronic Inpatient Medication Records, SAP, and Hospital Incident Reporting System. The sample consisted of 1506 cases (1:5 faller to non-faller). The fall prediction model was trained using the following four variables: demographics, diagnosis, medications, and surgery. Data sources included the hospital’s data repository, integrating admission/discharge, pharmacy, laboratory, and incident reports. Results: The support vector machine model performed best among all tested models, achieving an AUC of 0.803, recall of 0.816, and precision of 0.440. In the validation cohort (978 patients: 163 fallers and 815 non-fallers), the fall prediction model demonstrated moderate-to-good discrimination (AUC 0.79), with accuracy of 0.67, sensitivity of 0.46, and specificity of 0.86. Compared with the nursing four-item fall risk assessment, which showed lower discrimination (AUC 0.65, accuracy 0.65, sensitivity 0.58, specificity 0.72), the fall prediction model had better specificity and overall discrimination, though the nursing tool was more sensitive in identifying fallers. Conclusions: The fall prediction model using demographics, diagnoses, medication, and surgery data predicts falls risk effectively. It enables timely, accurate risk assessments and supports preventive interventions, saving nurses’ time for direct patient care.