DOI: 10.1039/d4nj04475d ISSN: 1144-0546
Development and validation of a high-throughput HPLC-MS/MS method for the simultaneous determination of exatecan and its cathepsin B-sensitive prodrug in rat plasma
Xiaolan Xu, Jing Li, Xiaohua Ran, Chenxia Bai, Qing Yan, Yangyang Liu, Qikun Jiang, Tianhong ZhangA reliable and high-throughput LC-MS/MS method was established and validated for simultaneous determination of exatecan and its cathepsin B-sensitive prodrug (C12-VC-PAB-Exa) in rat plasma and successfully applied to the pharmacokinetic study.