Development and Optimization of Transdermal Patch of Methimazole for the Treatment of Hyperthyroidism
Dhairya Trivedi, Tularam BarotAbstract
Background:
Antithyroid medications like methimazole are frequently used to treat hyperthyroidism, which is defined by an excess of thyroid hormone production. However, because of its short half-life, methimazole must be taken often by mouth, which might result in variable plasma concentrations and decreased patient compliance.
Aim and Objective:
In order to offer prolonged drug release, increase therapeutic effectiveness, and improve patient adherence, this study set out to design and optimize a transdermal patch formulation of methimazole.
Materials and Methods:
Methimazole and the excipients (pullulan, chitosan, polyvinyl alcohol, Transcutol, propylene glycol, and glycerol) did not significantly interact, according to Fourier transform infrared spectroscopy. Using a central composite design, the formulation was adjusted using response variables for drug flux, tensile strength, and folding endurance.
Results:
With 82.88% of methimazole diffusing across the test period,