DOI: 10.4103/jehp.jehp_1720_25 ISSN: 2277-9531

Determinants of preventive behaviors against liver fluke and cholangiocarcinoma in Laos: A TPB–based cross-sectional study

Phouthong Vanhnivongkham, Vanhnasak Seanthavisouk, Pattaraporn Charoenbut, Thamarak La-ongnual, Worathon Busabong, Sisouk Keomanivong, Nopparat Songserm
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BACKGROUND:

Opisthorchis viverrini (OV) infection remains a major public health issue in the Mekong Basin and a leading cause of cholangiocarcinoma (CCA). This study identified determinants of OV/CCA preventive behaviors in Champasak Province, Lao People’s Democratic Republic (PDR), using the theory of planned behavior and social support.

MATERIALS AND METHODS:

A community-based cross-sectional study was conducted from January to March 2025 among 577 residents aged ≥20 years in one city and nine districts of Champasak Province, southern Lao PDR. Participants were selected using multi-stage random sampling. Data were obtained through a validated structured questionnaire covering demographics, knowledge, perceived behavioral control, social support, and preventive behaviors. Data were analyzed using descriptive statistics, Pearson’s correlation, and multiple linear regression at a significance level of P < 0.05.

RESULTS:

Overall, 40.21% of participants had low knowledge, while 81.28% reported moderate preventive behaviors. Preventive behaviors were positively correlated with education, knowledge, perceived behavioral control, and social support, but negatively with age. Regression analysis showed that social support (β =0.36, 95% confidence interval [CI]: 0.28–0.44, P < 0.001), knowledge (β =0.21, 95% CI: 0.12–0.30, P < 0.001), and perceived behavioral control (β =0.18, 95% CI: 0.10–0.26, P < 0.001) were significant predictors. The final model explained 26.00% of the variance in preventive behaviors (adjusted R ² =0.26, P < 0.001).

CONCLUSION:

Social support, knowledge, and perceived behavioral control significantly influence preventive behaviors against OV/CCA. Strengthening community engagement and behavioral self-efficacy may improve long-term prevention outcomes.

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