DOI: 10.1039/d4ra06954d ISSN: 2046-2069
Design, synthesis, anticancer activity and molecular docking of quinoline-based dihydrazone derivatives
Jia-Xing Lu, Hai-Rong Lan, Dai Zeng, Jun-Ying Song, Ya-Ting Hao, Ai-Ping Xing, Ao Shen, Juan YuanQuinoline-based dihydrazone derivative 3b showed multiple anticancer mechanisms. 3b could not only induce apoptosis of MCF-7 cells and bind to DNA , but also act as a CDK2 inhibitor.