DOI: 10.1039/d6md00312e ISSN: 2632-8682
Design, synthesis, and X-ray structural studies of potent SARS-CoV-2 Mpro inhibitors containing tetrahydroisoquinoline-3-carboxamides as P2 ligands
Arun K. Ghosh, Ashish Sharma, Satyanarayana Iddum, Sydney N. Bogan, Uttara Jayashankar, Emma K. Lendy, Shin-ichiro Hattori, Nobuyo Higashi-Kuwata, Hiroaki Mitsuya, Andrew D. MesecarA series of potent SARS-CoV-2 Mpro inhibitors is designed, synthesized and evaluated. Inhibitor 5j and the X-ray structure of the SARS-CoV-2 Mpro–5j complex are represented.