Outline
DOI: 10.1039/d6ra07164c ISSN: 2046-2069
Design, synthesis and biological evaluation of novel artemisinin derivatives as potent P-glycoprotein modulators for overcoming multidrug resistance
Jerónimo Laiolo, Artemis Tsirogianni, Cecilia L. Barbieri, Mariana Belén Joray, Dafni G. Graikioti, Dimitra Toumpa, Jazmín Lavallén, Nicolás A. Rodriguez, D. Mariano A. Vera, Constantinos M. Athanassopoulos, María C. CarpinellaScreening novel artemisinin derivatives identified A16 and A20 as potent Rho123 efflux inhibitors (MEC: 49 nM), enhancing doxorubicin (Dox) cytotoxicity in K562/Dox cells at 50 and 5 nM, respectively.
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