DOI: 10.1039/d6ra06136b ISSN: 2046-2069
Design, synthesis, and biological evaluation of a new series of amide-linked chalcone derivatives as selective COX-2 inhibitors
Abida Shamim, Humaira Nadeem, Tajamul Hussain, Ayema Rehman, Syed Muzzammil Masaud, Sana Ayaz, Kashif Bashir, Muhammad Latif, Salman Alrokayan, Hussain Ali, Nadeem IrshadAmide-linked chalcone derivatives were designed, synthesized and evaluated using in silico , in vitro and in vivo studies for their potential to relieve pain and inflammation.