DOI: 10.1039/d6ra04928a ISSN: 2046-2069
Design, synthesis and antiproliferative activity of pyridone derivatives as potent enhancer of zeste homologue 2/histone deacetylase dual inhibitors
Zhaobang Tan, Jiajun Ding, Xin Chen, Lei Qian, Qiang YuThe pyridone-based compound 15c emerged as a dual HDAC/EZH2 inhibitor, exhibiting submicromolar antiproliferative activity and potent enzymatic inhibition, with molecular simulations rationalizing its binding mode to both targets.