DOI: 10.1039/d3md00300k ISSN:
Design, synthesis, and anti-hepatocellular carcinoma of thiopyrimidine/chalcone hybrids as dual STAT3/STAT5 inhibitors
Najla Altwaijry, Rehab Sabour, Mona H. Ibrahim, Omkulthom Al kamaly, Omeima Abdullah, Marwa F. Harras- Organic Chemistry
- Drug Discovery
- Pharmaceutical Science
- Pharmacology
- Molecular Medicine
- Biochemistry
New thiopyrimidine/chalcone hybrids were synthesized for hepatocellular carcinoma treatment. Compound 5h was the most active one. Additionally, it displayed STAT3/STAT5 dual inhibitory action which was confirmed by western blot analysis.