DOI: 10.1039/d6ra09088e ISSN: 2046-2069
Design, click synthesis, and biological evaluation of novel uracil-1,2,3-triazole hybrids as dual EGFR/CDK1 inhibitors: antiproliferative activity, mechanistic insights, and in silico studies
Asmaa H. Mohamed, Ashraf A. Aly, Elshimaa M. N. Abdelhafez, Aya A. Fouly, Alan B. Brown, Sageda A. GedamyA novel series of uracil–1,2,3-triazole hybrids was designed, synthesized, and evaluated as dual EGFR/CDK1 inhibitors to target cancer cell proliferation and survival.