DOI: 10.1039/d6ra03616c ISSN: 2046-2069
Design and synthesis of isoxazolidine core-based selective COX-2 inhibitors: in vitro inhibitor activity and in silico modeling
Arwa Al-Adhreai, Mohammed ALSaeedy, Demokrat Nuha, Muhammed Trawally, Ramzan ullah, Syed Mansoor Ali, ZabnAllah M Alaizeri, Selahaddin Güner, Mansour K. GatashehA novel series of tricyclic isoxazolidine–imidazole derivatives (3a–l) bearing substituted phenyl groups was designed, synthesized, and evaluated as selective cyclooxygenase-2 (COX-2) inhibitors. The graphical abstract image was partly generated with Google Gemini.