Descriptive Laboratory Profiles in a Nasopharyngeal Pathology Extract: An Exploratory Profile-Level Case—Comparison Study with Qualitative Endoscopic Image Review
Darius Radu Roman, Carmen Delia Nistor Cseppento, Dana Carmen Zaha, Timea Claudia Ghitea, Alexia Manole, Dana Zdremtan, Alexandru Chioreanu, Octavian Dragos Palade, Felicia ManoleBackground: Routine laboratory measurements require reliable source linkage and independent observations before clinical interpretation. We descriptively examined an extract containing records labeled as nasopharyngeal carcinoma (NPC) or benign adenoid-associated pathology. Methods: This retrospective, single-center analysis concerned 72 recorded rows, comprising 36 NPC-labeled and 36 benign-labeled records. Identical non-demographic vectors were summarized as 12 NPC-labeled and 24 benign-labeled physiological profiles, without treating these as confirmed independent patients. An undocumented hepatic inflammatory score was excluded. The AST-to-platelet ratio index (APRI) was calculated post hoc using an AST upper reference limit of 33 U/L and summarized descriptively. Endoscopic images and their analysis were excluded because image-to-record linkage and publication authorization were not verified. Results: Each of the 12 NPC core profiles, defined by the recorded inflammatory score, C-reactive protein, erythrocyte sedimentation rate, and leukocyte count, occurred three times in the extract. The median APRI was 0.289 (IQR 0.239–0.336) in NPC-labeled profiles and 0.337 (IQR 0.288–0.405) in benign-labeled profiles. These distributions describe recorded laboratory vectors and do not establish patient-level group differences or biological associations. Conclusions: The extract contains repeated laboratory patterns whose origin and patient-level independence remain unresolved. Source-record verification is required before clinical inference. The descriptive summaries do not establish a hepatic phenotype, diagnostic performance, prognosis, or disease-specific biological mechanism.